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High-Dose Protocols: Some dermatologists may administer doses up to 2400 mg per session, especially for individuals with stubborn pigmentation or darker skin tones

Parameters for which we had experimental evidence were fixed based on available data

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While experimental and computational studies suggest that both the sulfur and selenium variants proceed through a double [2,3]-sigmatropic rearrangement, the sulfenylation reagents behave as coupling partners while organoselenium reagents can be employed catalytically