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Prolonged and continuous misuse of peptides can lead to a range of adverse effects, including: Long-Term Effects Long-term substance abuse can lead to a variety of negative effects on the body and mind, including: Organ damage (e.g., liver, kidneys, heart) Cardiovascular problems (e.g., heart attack, stroke) Hormonal imbalances Reproductive system dysfunction Weakened immune system Impaired cognitive function Psychological disorders (e.g., anxiety, depression) Increased risk of substance dependence Development of tolerance and withdrawal symptoms These long-term effects highlight the potential dangers and risks associated with peptide abuse

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10.1038/nn.3526 246 SarmaB

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Puthanveetil P, Wang F, Kewalramani G, Kim MS, Hosseini-Beheshti E, Ng N, Lau W, Pulinilkunnil T, Allard M, Abrahani A, Rodrigues B (2008) Cardiac glycogen accumulation after dexamethasone is regulated by AMPK