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This is likely also the case during systemic viral infections that result in severe oxidative stress (cell/tissue necrosis), a usual indication of late and failed attempts by the host to induce resistance (Hernndez et al., 2016)

In obesity, adipose cells lose their ability to store excess lipids effectively, leading to ectopic fat deposition in organs such as the liver and muscles

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Some studies report a statistically significant decrease in the GPx activity of HFD-fed obese rodents as compared to their lean counterparts (Huang et al

This has been known to lead to thyroid related autoimmune conditions like Hashimoto's thyroiditis and Graves' disease, two diseases that can cause an enlarged thyroid gland and a host of additional symptoms and complications