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3 As demonstrated in 10,142 patients in the longest CV outcomes program for a type 2 diabetes therapy, INVOKANA reduced A1C, body weight, and systolic BP for adult patients with T2D 1 CANVAS A1C: placebo-subtracted mean change from baseline Body weight: placebo-subtracted mean change from baseline Systolic BP: placebo-subtracted mean change from baseline A1C: placebo-subtracted mean change from baseline Body weight: placebo-subtracted mean change from baseline Systolic BP: placebo-subtracted mean change from baseline AHAs=antihyperglycemic agents

Semaglutide has an isoelectric point of approximately 5.4, which means it is least soluble and least stable at or near this pH

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