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In particular, long-term use of non-steroidal anti-inflammatory drugs (NSAIDs) can cause gastric mucosal damage as they can inhibit mitochondrially encoded cytochrome C oxidase I (MT-CO1, also known as COX-1) and block its protective effect on gastric mucosa

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In HFD-induced atherosclerotic mice, BBR treatment exerts a beneficial effect on reducing circulating lipid levels (Wu et al., 2020) by increasing the abundance of Akkermansia, Firmicutes, and Verrucomicrobia (Zhu et al., 2018) and decreasing the abundance of Bacteroidetes and Proteobacteria in the mouse intestinal flora (Shi et al., 2018)

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