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Retatrutide (also designated LY3437943) is a synthetic, investigational-grade peptide engineered as a unimolecular triple agonist targeting three key metabolic receptors simultaneously: the glucagon-like peptide-1 receptor (GLP-1R), the glucose-dependent insulinotropic polypeptide receptor (GIPR), and the glucagon receptor (GcgR)

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These include: Thioredoxin/Glutathione Reductase (TGR), selenoprotein V, selenoprotein W, selenoprotein K, selenoproteins 15 and selenoprotein S [1]

A boxed warning addresses thyroid C-cell tumor risk seen in rodent studies, and use is contraindicated with a personal or family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2

Athletic Performance Impairment Perhaps most striking: caffeine doesn't uniformly enhance performance