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In non-alcoholic fatty liver disease, several pathophysiological arguments suggest (in the absence of proof from clinical trials) that long-term methotrexate therapy worsens liver damage and the progression of liver disease

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Your physician can manage the transition using a dose conversion chart to determine your starting tirzepatide dose based on your current semaglutide dose

Any deviation from licensed dosing regimens should only occur under close medical supervision, as the risk-benefit profile at sub-therapeutic doses remains poorly characterised and may not provide the intended clinical outcomes