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however, the specific upstream molecular regulators of this effect warrant further investigation

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For Empagliflozin 21 pregnancies were reported of which 8 listed the corresponding pregnancy outcomes: 2 spontaneous abortions, 1 elective termination, 1 ectopic pregnancy, 3 healthy infants without congenital anomaly, 1 premature infant

Given the observed improvements in fasting glucose, OGTT performance, and HbA1c levels, it's no surprise that homeostasis model assessment of insulin resistance (HOMA-IR) scores in all three groups dropped by 8% (200mg/day), 7% (400mg/day), and 6% (800mg/day)