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Ten-eleven Translocation (TET) enzymes converts methylcytosine (m 5 C) to hydroxymethylcytosine (hmC), which is not recognized by Dnmt1, it is believed to exclude maintenance methylation allowing for passive demethylation, and it is an intermediate in the active conversion of m 5 C to cytosine (C) 27

Even when acting to reduce H 2 O 2 , their most important function may be in oxidizing the co-substrate rather than removing ROS (OBrien et al

Moreover, for patients resistant to MET inhibitors, the potential of PD-1/PD-L1 inhibitors to reverse or ameliorate resistance is an area ripe for exploration