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Follow a gradual dose escalation schedule: Weeks 1-4: 0.25 mg Weeks 5-8: 0.5 mg Weeks 9-12: 1 mg Weeks 13-16: 1.7 mg From Week 17 onwards: 2.4 mg (maintenance dose) Rotate injection sites to prevent skin irritation or reactions

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48,81124 Upon sensing the activation signal, NLRP3 recruits the adaptor protein ASC and pro-caspase-1, leading to inflammasome complex assembly

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