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Dec 2006;2(4):360-74

Additionally, we extended our focus to RIP1 and RIP3, which are key inducers of necroptosis in the early phase of APAP toxicity, manifesting effects within 2 h of administration (Liu et al

Basally located melanocytes are increased in number

Side effect rates at 12mg are meaningfully higher than at 8mg: Nausea: 43.2% of participants (vs 38.1% at 9mg) Diarrhea: 33.1% (vs 34.7% at 9mg) Constipation: 25.0% (vs 21.8% at 9mg) Vomiting: 20.9% (vs 20.4% at 9mg) The decision between 8mg, 10mg, and 12mg as a maintenance dose should be made based on individual response

pp 109118 Costa A, Martignoni E, Bono G, Monzani A, Nappi G