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Because the peptide amplifies the body's own hormonal axis rather than replacing GH directly, its effectsboth desired and adverseare largely downstream consequences of elevated GH and IGF-1

POINTER study, which enrolled participants from diverse backgrounds across multiple cities

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The exact reasons are not fully understood, but potential factors include genetic differences, interactions with other medications, and underlying health conditions that may reduce the effectiveness of GLP-1 drugs for weight loss in certain people

A PubMed search was conducted using a structured search strategy comprising the following terms: combination GLP-1RA and basal insulin