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This downregulation inhibits RASF apoptosis, consequently promoting synovial hyperplasia

Weeks 1-4 Starting dose Weeks 5-8 First increase Weeks 9-12 Therapeutic level Weeks 13-16 Near target Week 17+ Full dose Side Effects & Safety Most side effects are mild and temporary, occurring during the dose increase phase

Environ Health Perspect 103(suppl 6):7376 Rognan D, Mus-Veteau I (2014) Three-Dimensional structure of the smoothened receptor: implications for drug discovery

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Beyond 12 months: Weight maintenance becomes the focus