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Although the usage of anti-VEGF led to an increased breast CSCs, through induction of hypoxia [262], in the CSCs population of NSCLC, combination therapy of anti-hepatoma-derived growth factor (HDGF) antibody and VEGF tyrosine kinase inhibitor was successful in diminishing this population [323]

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Originally developed to manage type 2 diabetes, Semaglutide has been shown to significantly reduce body weight by working on the brains appetite-regulating centers

Moreover, a randomized, evaluator-blinded clinical trial including 40 Brazilian women with facial melasma who underwent broad-spectrum tinted sunscreen and nightly application of 5% cysteamine or 4% HQ for 16 weeks resulted in an MASI reduction of 32% and 52%, respectively [31]