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Moreover, some stakeholders have questioned the use of capitated managed care programs for vulnerable populations out of concern that narrower provider networks and reduced reimbursement rates may create a barrier to access and adversely affect the quality of care (Solomon, 2012)

The mechanism likely involves both the opiate receptor effects and DSIP's normalization of stress hormones, which become dysregulated during addiction and withdrawal

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The latter increases with increasing purulence owing to the presence of cellular debris

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