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10.1111/1471-0528.17045 239 WiserA.GonenO.GhetlerY.ShavitT.BerkovitzA.ShulmanA
R The key catalytic mechanism involves lowering the pKa of the glutathione thiol from 9.0 to approximately 6.5, generating the thiolate anion (GS) at physiological pH, which is a potent nucleophile
Table 4 Key translational barriers for functional-food anticancer agents and practical paths forward
[DOI] [PubMed] [Google Scholar] 9
[7] A real-life approach to consideration of MS might suggest that virtually any acute or chronic stressor that weakens the immune system toxic attack, intensified oxidative stress, illness from a garden variety virus or bacterium, malnutrition, even sustained emotional stress could conceivably create a time window for one of these organisms to enter the brain and establish itself
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