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Supplementary material The Supplementary Material for this article can be found online at: References 1 WHO Coronavirus (COVID-19) Dashboard | WHO Coronavirus (COVID-19) Dashboard with Vaccination Data

Another important miRNA regulating cell metabolism is miR-378/378*, embedded within gene encoding peroxisome proliferator-activated receptor gamma coactivator 1-beta (PGC-1), a transcriptional regulator of oxidative energy metabolism

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99-101 Some evidence suggests long-term berberine use, especially at high doses, may impair some aspects of cellular metabolism in specific types of cells