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However, these molecular mechanisms need to be further elucidated ( 2 The AMPK pathway AMPK is a serine/threonine kinase comprised of a catalytic alpha subunit and two subunits of beta and gamma regulators ( 3 The relationship between AMPK and antidiabetic drugs Metformin, the most widely used oral agent for the treatment of T2D, is historically known as an AMPK activator ( 3.1 SGLT2i and AMPK The SGLT2i (Sodium-glucose co-transport 2 inhibitors) are a class of antidiabetic agents, targeting the major glucose transporter SGLT2 in the kidney

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While there is research showing that GH treatment can result in the reduction of fine lines and wrinkles by promoting collagen growth and repair of skin tissue, a review by Bartke A et al into growth hormone and aging concluded that elevation of GH levels into the supranormal (pathological) range is associated with increased disease risks and reduced life expectancy likely representing an acceleration of aging [17]