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Corti A, Dominici S, Piaggi S, Belcastro E, Chiu M, Taurino G, Pacini S, Bussolati O, Pompella A

The above results demonstrated that methylated UBE2m inhibited PPAR-mediated fatty acid metabolism by neddylating NEDD4

doi: 10.1111/exd.12621 46 BeschRPoeckHHohenauerTSenftDHackerGBerkingCet al

It binds with high affinity across multiple melanocortin receptor subtypes: MC1R (Ki approximately 0.67 nM), MC4R (approximately 6.6 nM), MC3R (approximately 34 nM), and MC5R (approximately 46 nM)