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Most studies and sources report no known direct interaction between caffeine and semaglutide, the active ingredient in Ozempic and several other GLP-1 medications
surrogate subtype was not available for 3% of the cases
Together, they demonstrate the clinical viability of the GLP-1/glucagon dual-agonist concept and suggest that this mechanism class will be a significant addition to the metabolic disease treatment landscape alongside tirzepatide and emerging triple agonists like retatrutide
doi: 10.1016/0014-5793(88)80821-4
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