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Abstract Circadian rhythms orchestrate nearly all physiological and behavioral functions, and their deterioration with aging contributes to sleep disruption, cognitive decline, and increased vulnerability to disease

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Orforglipron, by contrast, is a chemically synthesized, non-peptide GLP-1 receptor agonist

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many of them together with Nrf2-activating action are also able to inhibit NF-B or STAT3/5 [166], thus contributing to reducing inflammation (Figure 6)