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In contrast, shared decision-making should guide care for those with multiple comorbidities, history of significant rebound weight gain, and difficulty maintaining dietary and physical activity modifications long term because they may require ongoing treatment.

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USA 100 , 1015810163 (2003)

Most gastrointestinal side effects are dose-dependent and tend to be most pronounced during treatment initiation or dose escalation

A definitive diagnosis is made by finding increased levels of cystine in polymorphonuclear leucocytes