fda compounding semaglutide enforcement news november 2025 The announced plans to take action against non-FDA-approved GLP-1 receptor agonists, a move that prompted telehealth company Hims & Hers to yank its new compounded (Wegovy) weight-loss pill from the Congress Introduces SAFE Drugs Act

Duan Z, et al

They are not FDA-approved and may lack the uniform quality and safety standards of brand-name drugs like Ozempic or Wegovy

Acknowledgements The authors thank their funding agencies, the Singapore Ministry of Health, Ministry of Education and Ministry of Trade, the National Medical Research Council, Singapore, and the Singapore Agency for Science, Technology and Research, for grants NMRC/CSA/0054/2013 (P.M.Y.), NMRC/BNIG/2025/2014 (R.A.S.), IA/I/16/2/502691-Wellcome Trust/DBT India Alliance Intermediate Fellowship (R.A.S.) and NMRC/OFYIRG/0002/2016 (B.K.S.)

While pharmacological treatments and phytochemicals could provide symptomatic relief and neuroprotective effects, their efficacy is hindered by poor bioavailability, systemic side effects, and restricted BBB penetration

Kapitulnik, J., Levin, W., Conney, A