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SE: Resources, Writing review & editing, Conceptualization, Funding acquisition, Project administration, Supervision, Writing original draft

Fucini: Writing review & editing, Writing original draft, Visualization, Validation, Supervision, Software, Resources, Project administration, Methodology, Investigation, Funding acquisition, Formal analysis, Data curation, Conceptualization

S.R, T.K, and R.H.C performed the mouse, muscle force and mitochondrial experiment and analyzed data

Case Presentation We present a case of colonic ischemia in a young patient who experienced significant nausea, vomiting, and abdominal pain after initiation of semaglutide

Many proteins which underwent dysregulated abundance under both basal and ROS conditions were reductases, oxidases, stress response proteins and enzymes with oxidising products (Supplementary Tables S3 and S4)