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Individuals with the rs662 AA genotype have a lower lung cancer risk in non-smokers and lower levels of the oxidative stress marker 8-OHdG, suggesting that PON1 gene polymorphisms co-regulate lung cancer occurrence and oxidative stress levels in conjunction with environmental factors [252]

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As people grow older, the natural production of growth hormone declines, leading to increased body fat, reduced muscle mass, and other ageing effects

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