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The combination of GLP-1 and GIP creates dual action, which promotes greater weight loss and metabolic improvements as compared to other GLP-1 weight loss drugs such as semaglutide (Wegovy)

However, in epithelial cells such as those in the small and large intestines, more transitory p53 activation is associated with transient expression of its target genes

In the muscle atrophy model induced by a high-fat diet (HFD), the two GLP-1RAs liraglutide and semaglutide, effectively improved the state of muscle atrophy by regulating the balance of muscle protein metabolism

10.1016/j.exger.2021.111544 234 ParkH.PooM

Responding to CNNs request for comments, Novo Nordisk acknowledged that gastrointestinal (GI) events are commonly associated with the GLP-1 class, emphasizing that most GI side effects related to semaglutide (the active ingredient) are generally mild and short-lasting