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Glucocorticoid-Related Signaling and Side-Effect Models Glucocorticoids, while clinically valuable in many inflammatory and immune-mediated conditions, can induce catabolic side effects: Catabolism and Tissue Integrity: Prolonged glucocorticoid exposure is associated with muscle wasting, increased fat accumulation, and reductions in bone density in experimental systems

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May be given into a vein by IV May be given as a tablet by mouth May be given as a liquid by mouth Diarrhea Nausea Vomiting Upset stomach Abdominal (belly) pain Body odor Chest pain High blood pressure Swelling of the face, feet, or legs Skin irritation Changes in body weight Loss of appetite Change in taste Dark colored stools Headache Dizziness Vision changes Cough or runny nose Fever Allergic reaction Call your care team right away if your child has symptoms of an allergic reaction

Oimomi M, Maeda Y, Hata F, et al

The decision belongs with your endocrinologist or primary care provider familiar with your full immune and thyroid history