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In vertebrates, the pre-proglucagon polypeptide is a product of the GCG gene, which encodes four peptide hormones: glucagon, glucagon-like peptide-1, glucagon-like peptide-2 and oxyntomodulin 50

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may have important implications on the accessibility and adherence of these drugs in the future, [because] currently all agents approved for weight loss are injections. The results showed frequent adverse events during the trials, ranging from 80% to 97% for GLP-1 receptor agonists and coagonists and 63% to 100% for placebo