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In addition, 8-oxo-Gs accumulate at telomeres, where they inhibit telomerase and decrease the binding of telomeric proteins, leading to the disruption of telomere length and precluding the maintenance of chromosomal-end capping 46

This shift does not diminish the importance of safety, but it underscores the need to evaluate peptide systems within an appropriate therapeutic context rather than through overly conservative early-stage filters

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