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As you can see in Figure 1, the MTHFR enzyme catalyzes one of the reactions that must take place before the conversion of the amino acid homocysteine to the amino acid methionine

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In sum, SAMe is a key regulator of Met metabolism, and Met concentration is closely related to the level of SAMe ( Figure 2 Figure 3 Met metabolism is closely linked to various metabolic pathways such as folate cycle and transsulfuration pathway ( 3

In turn, the oxidized vitamin C, thanks also to GSH, can revert to its reduced form ( 2.3

Researchers have shown that encapsulation increases plasma levels and enhances biodistribution to tissues involved in oxidative stress and aging, including the liver, skin, and mitochondria