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Moreover, britanin, a bioactive terpenoid extracted from Inula lineariifolia , increased intracellular GPX4 and GSH levels and diminished ferroptosis-induced MIR injury via AMPK/GSK3/Nrf2 signaling [90]

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However, one iron chelator (deferoxamine mesylate) and one antioxidant agent (vitamin E) were capable of inhibiting cell death triggered by RSL, indicating the effects of iron as well as reactive oxygen species (ROS) ( RAS mutations by Mechanism of ferroptosis Ferroptosis has a distinctive morphological alteration compared with other PCDs such as apoptosis, necrosis, pyroptosis, and autophagy

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L-carnitine represents a small molecular weight amino acid derivative synthesized through metabolic pathways involving two indispensable amino acids: methionine and lysine