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Figure 2 4.1 Passive diffusion Small nanoparticles move down their concentration gradients by a mechanism of transport known as passive diffusion, which is a nonspecific and energy-free mode of transport ( 4.2 Efflux pumps ATP hydrolysing proteins embedded in the endothelial membranes also facilitate the transfer of molecules across the BBB using the energy generated from ATP breakdown

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Thapsigargin, a histamine secretagogue, is a non-12-O-tetradecanolphorbol-13-acetate (TPA) type tumor promoter in two-stage mouse skin carcinogenesis

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