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16 Domperidone , another D2 antagonist, is as effective as metoclopramide for relief of symptoms, and it does not cross the blood-brain barrier in sufficient quantity to cause the neurologic side effects seen with metoclopramide

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In contrast, evidence from a Norwegian nested case-control study involving hospital nurses demonstrated statistically significant telomere shortening associated with long-term NS ( 6 consecutive nights, for 5 years)

This dual action distinguishes it from single-action GLP-1 agonists like semaglutide and may explain why some patients achieve stronger weight loss outcomes with tirzepatide

Palchesko RN, Romeo JD, McGowan KA, Gawalt ES