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New England Journal of Medicine (2016).

It is very plausible that these patients that have poor blood glucose regulation have faults in their upper digestive tract and those bitter receptors and the sweet receptors that are regulating the production of the GIP and the GLP-1 may not be doing their thing properly or the L cells may be receiving the signal but are not healthy enough to produce enough GLP-1

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Expected commercial pricing after FDA approval will likely mirror tirzepatide (Zepbound) roughly $1,0001,350/month list, with discounts through manufacturer direct-pay programs for cash-pay patients