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For weight management, NICE recommends these medications as an adjunct to lifestyle modification in specialist weight management services, with specific BMI thresholds (typically 35 kg/m or 32.5 kg/m in certain ethnic groups) with comorbidities, and usually for time-limited periods (up to 2 years for semaglutide)

Semaglutide enhances insulin secretion solely through GLP-1 receptor activation, while tirzepatide adds GIP-mediated insulin release on top of that