doi: 10.1016/j.plaphy.2013.05.032
Naturally occurring bioactive compounds, including flavonoids, terpenoids, polysaccharides and coumarin derivatives, all of which have been previously demonstrated to exhibit antioxidant and anti-inflammatory properties, are now becoming increasing recognized to possess anti-melanogenesis functions (44,45)
The neuronal loss and atrophy were particularly evident in the CA1 region of the hippocampus and layers II-III of the cerebral cortex
Interestingly, the interacting residues with the selected flavonoids were known as active residues in tyrosinase 37 and have been cited for interactions with potent tyrosinase inhibitors 92,93,94,95,96
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