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The 5-HT4 receptor, specifically expressed in the prefrontal cortex and limbic system (including the hippocampus and amygdala), regulates learning, memory, and cognitive function [58, 59]

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Of note, SARS-CoV-2 and RSV were also sensitive towards inhibition when the compounds were given after infection, indicating that in addition to the effects on entry, metabolism is also relevant for the observed antiviral activity

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Conditions such as obesity and type 2 diabetes are major risk factors for MASH, prompting interest in treatments that can address multiple aspects of metabolic syndrome