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The year is 2026, and the landscape for GLP-1s has undergone a significant, sometimes dramatic shift

"Hyperpigmentation is usually very focused, whereas melasma appears as broad patches with intervening areas of clearing," says Anthony Rossi, MD, a board-certified dermatologist in New York City

As in this group of patients B12 symptomology often is not recognized and the effect of oral supplementation regularly is insufficient (as a result of the destruction of intrinsic factor production, among other things), a large number of them suffer from B12 deficiency