Each trial sets its own criteria, so review the eligibility tab on each listing
Tetrahydrobiopterin (Dissing et al., 1989) and L-threo-3,4-dihydroxyphenylserine (precursor or noraderenalin or norepinephrine NE) (Maruyama et al., 1994) increased CSF HVA levels in PD patients, but to a lesser extent than levodopa
For many patients, it is the safest and most comfortable way to transition forward
The concentrated product was loaded onto a Superdex 200 increase 10/300 GL column with SEC running buffer containing 20 mM HEPES, pH 7.5, 100 mM NaCl, 10 mM MgCl 2 , 100 M TCEP, 2 M peptide 20, 0.00075% LMNG, 0.00025% GDN and 0.0002% (w/v) CHS
But if your insurance requires Saxenda for step therapy, completing that trial may be faster than fighting the requirement