The HGF/c-Met axis has a pivotal role in normal liver growth, regeneration, and protection (Figure 1) via canonical or non-canonical pathways to regulate cell proliferation, movement, differentiation, invasion, angiogenesis, and anti-apoptosis
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Circulation 144 (24), 18991911
Most human study data does start on a lower dose of 100 to 200 milligrams of NMN, slowly working up to 500 milligrams, according to Jillian Robillard, MS, RD, LDN
Science 339 , 12901295 (2013)