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Bhatia R

65.3% of participants on 12 mg ended the 80-week trial with a BMI under 30 meaning they no longer met the clinical definition of obesity

Combining treatments can increase the risk of side effects and may not be safe

This situation is also accompanied by the altered efficacy of G-protein stimulation in opioid-sensitive CNS structures and a reduction in the expression of several opioid receptor mRNAs, which indicates that NP can recruit and modify several opioidergic circuits in the brain [139]