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Research indicates that TGF-1 modulates renal injury by stimulating downstream Smads, where Smad3 is a key mediator that promotes renal fibrosis, Smad2, and Smad7 have renal protective effects, and Smad4 exhibits both promotion of fibrosis and inhibition of inflammation through different mechanisms (191)

It's not a protein because even though it's an amino acid chain, it's not considered protein, it's considered a small peptide, but it's most abundantly produced in human bodies

Amino Acids 42 , 199205 (2012)