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However, while central pharmacodynamics is an important factor influencing drug intake, peripheral pharmacokinetics can also have a profound effect on intake and even neural response to the same drug 56,57

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When to contact your provider: Persistent vomiting (more than 12 hours) Severe abdominal pain Signs of pancreatitis (pain radiating to the back, fever, rapid pulse) No weight loss after 8 weeks at the same dose Hypoglycemic symptoms (shakiness, confusion, sweating) if you're on other diabetes medications The 16-week decision point: At 16 weeks (four months), you and your provider should evaluate total weight loss

Gradual Tapering of GLP-1 Medications Instead, we recommend working with your doctor to taper off the medication gradually