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The efficacy of liraglutide on weight management was subsequently surpassed by semaglutide, which, when administered weekly at a dose of 2.4 mg in obese patients without diabetes, resulted in a weight reduction of 12.4% compared to placebo in the STEP 1 study [46], and a reduction of 9.4% compared to liraglutide 3.0 mg in the STEP-8 study [47]

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The Cleveland Clinics long-term data showed: Over 10 years, surgical patients lost on average 21.6% of their TBW versus only 6.8 % lost by GLP-1 users

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