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Several recent studies identified that a particular F-box protein, FBXO22, which is overexpressed in several cancers 8 , can be harnessed for TPD of several neosubstrates, including NSD2 (nuclear receptor-binding SET domain-containing 2), XIAP (X-linked inhibitor of apoptosis protein), FKBP12 (FK506-binding protein 12), and SMARCA2/A4 (SWitch/Sucrose nonfermentable (SWI/SNF) complex ATPases)

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A large study of previously untreated patients demonstrated that a long duration of viral negativity with a less sensitive test was associated with SVR,[22] underscoring the importance of accurate determination of HCV RNA-negative status