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Table 2 Agents reviewed with their MOA, phase of development, trial data, and associated biopharmaceutical companies, for target populations without type 2 diabetes

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In a mouse model of myocardial infarction, directly transplanted exogenous mitochondria derived from mesenchymal stem cells were better at protecting cardiac function than mitochondria derived from skin fibroblasts

The problem is context: the near-total absence of human clinical data, contaminated supply chains, the absence of medical oversight, and an information ecosystem that systematically understates risk while overstating benefit