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They compete for absorption and can cause irritation
GHK-Cu and AHK-Cu are structurally related copper-binding peptides studied for their roles in Wnt/beta-catenin signaling in hair follicle stem cells, dermal papilla cell proliferation, and anagen phase initiation
However, the exposure to BPC-157 appeared to significantly reduce plasma extravasation, histological alterations potentially associated with inflammation, and alveolar bone resorption
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That substitution is thought to shift the peptide's affinity more specifically toward hair follicle cells, rather than toward the broader tissue-repair profile of GHK-Cu
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