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Some patients find that remaining at a lower maintenance dose, whilst potentially sacrificing some glycaemic or weight loss benefits, provides an acceptable balance between efficacy and tolerability

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Back Thorens, B, Hodson, DJ (2024) Building the glucagon-like peptide-1 receptor brick by brick: Revisiting a 1993 Diabetes Classic by Thorens et al, Diabetes, 73, 1027-31

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19 The Trial to Evaluate Cardiovascular and Other Long-term Outcomes with Semaglutide in Subjects with Type 2 Diabetes (SUSTAIN) trials with semaglutide also demonstrated a reduction in HbA1c levels, body weight, and cardiovascular events in individuals with type 2 diabetes