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10.1161/01.RES.0000338597.71702.ad 144 PiccaA.CalvaniR.Coelho-JniorH

Heavy drinkers with depressive symptoms typically exhibit (1) later age of MDD onset (post-25 years), (2) predominance of somatic symptoms (e.g., fatigue, insomnia) over cognitive rumination, and (3) partial responsiveness to selective serotonin reuptake inhibitors (SSRIs), which may reflect underlying serotonergic deficits compounded by ethanols neurotoxic effects (Pedrelli et al

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A marked attenuation and reversal (medication at the maximum of amphetamine-disturbances) of both stereotyped behavior and increased excitability (i.e., stronger and violent twitching, panic jumping and escaping) were regularly noted