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discovered that LPCAT1 can promote the palmitoylation of histone H4, leading to an increase in mRNA synthesis, and thereby mediating the progression of castration-resistant prostate cancer (CRPC) [70]

The same pattern likely applies to both CagriSema and tirzepatide, though long-term discontinuation data for both is limited

This modification eliminates the oxidation-prone thioether side chain present in native -MSH, substantially improving the peptides chemical stability without compromising receptor engagement

10.1038/s41374-018-0170-0 [DOI] [PubMed] [Google Scholar] 17.Wang RF, Xue GF, Hlscher C, Tian MJ, Feng P, Zheng JY, Li DF

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